It actually seems like the Big Mom Germa 66 Alliance is the enemy this arc. Both crews are insanely evil. It is much more obvious that they will fight Big Mom though. Lets look at some evidence to see if the SHs will fight Germa Strawhats vs Big Mom 0) Nami might get a favor from Big Mom from Lola = a little favor here 1) Big Mom hates Luffy because of everything he has said and done = they are gonna fight 2) Purin seems like a nice girl = maybe a little favor from Big Mom, but seeing as she uses her daughters probably not 3) Luffy likes Jinbe a lot and Mama hurt Jinbe so Luffy will hate Big Mom = Luffy is definetely going to want to punch her 4) Luffy/Nami/Chopper/Carrot already started fighting the Big Mom pirates = pretty self explanitory 5) Pedro and Brook are going to steel from Big Mom Straw Hats vs Germa 66 0) Sanji has a bad relationship with his parents = Strawhats would help Sanji to get him back 1) Yonji tried to fight Strawhats, but Reiju stopped him = so there is nothing conclusive here 2) Sanji already fought Yonji = nothing conclusive here either, could have just been a sibling squabble 3) Sanji is about to fight his Dad. if he wins = SHs will fight BM if he loses = SHs will find out and try to fight Germa to free him 4) Ichiji and Niji are unpredictable at this point = ? In conclusion SHs will definitely fight Big Mom and may fight Germa 66. It is really up in the air depending on what happens between Sanji and his Father. My guess is that Sanji will be completely outmatched, but all we know from the latest chapter is that Judge defeated some unnamed king to conquer the north blue. We don't know how strong Sanji is either so it really could go either way. My idea is that Sanji will lose and SHs will have to fight an alliance of Big Mom and Germa 66 (which btw is looking pretty bad for the SHs). The only thing I can say for sure is that Luffy is going to fight Big Mom.